What is likely to happen if blood supply to an organ is severely reduced?

When blood supply to an organ is severely reduced, the most significant consequence is tissue death, also known as necrosis. Blood is essential for delivering oxygen and nutrients to tissues while also removing waste products. Without adequate blood flow, cells begin to suffer from a lack of oxygen (ischemia) and nutrients, leading to cellular injury and, ultimately, cell death if the condition persists.

In contrast, inflammation typically follows tissue injury but is not a direct result of blood supply reduction. It acts as a response mechanism rather than a direct consequence. Keloid formation is associated with abnormal healing processes and excessive scar tissue development, and swelling often arises from fluid accumulation as a response to injury or inflammation, but neither of these directly correlates with the lack of blood flow to an organ. Hence, when evaluating the outcomes of severely reduced blood supply, tissue death stands out as the most direct and critical effect.